What is Sildenafil ?
Sildenafil (also referred to as sildenafil citrate) is a medicine that is generally used to medicate erectile dysfunction and, in some cases, pulmonary arterial hypertension, or PAH. It is distributed by such famous trade names, as Viagra and Revatio. Sildenafil was evolved by a group of British pharmaceutical scientists, who worked at Pfizer's research facility in Sandwich, Kent. Originally, the drug was researched for the treatment of angina pectoris and hypertension. The first medical tests were performed in Morriston Hospital, in Swansea. The first phase of tests suggested that the medicine had poor influence on angina, but that it might prompt penile erections. It was discovered in the end that sildenafil acts by suppressing cGMP-specific phosphodiesterase type 5 - a ferment, which delays cGMP degradation - that regulates flow of blood in the penis. The medicine got its patent in 1996 and became approved for use in impotence treatment by the US FDA on 27th of March, 1998. It became the first oral medicine approved for the medication of erectile dysfunction in the USA. It was offered for sale in the US later the same year. Sildenafil under the name of Viagra soon became a tremendous success as its annual sales peaked at 1,934 million US dollars in 2008.
Sildenafil's Mechanism of Action
Sildenafil's mechanism of action involves the defense of cGMP from PDE5 degradation in the cavernous body. Nitric oxide in the cavernous body of the penis links to guanylate cyclase receptors, which causes higher cGMP levels that lead to smooth relaxation of muscles of helicine arteries' intimal cushions. This relaxation causes vasodilation and augmented blood inflow into the penis's spongy tissue, which results in an erection.
Sildenafil is a strong selective cGMP-specific PDE5 suppressor, which responds for cGMP degradation in the cavernous body. The drug's molecular structure is akin to that of cGMP, acting as a concurrent linking PDE5 agent in the cavernous body, which causes better erections due to increased cGMP levels. However, if no sexual stimulation is caused, sildenafil won't result in an erection.Tretinoin .025 Buy Tretinoin retin a and sun exposure. Erectile defunction buy tadalafil sexual aids for erectile dysfunction.
Sildenafil is metabolized by liver ferments and is emitted by both kidneys and the liver. In case the drug is consumed with a high-fat meal, its absorption is decreased. The time you would need to wait for a good result is about an hour, when you administer a 50 mg Sildenafil pill. If you are taking 100 mg Sildenafil pills, you should ask either your doctor or a pharmacist at the neighbor drug-store. The greatest thing is that you can always buy sildenafil online!
Sildenafil should be taken exactly as your doctor has prescribed. You shouldn't take it in greater or lesser portions or for longer periods, than recommended. Follow the instructions in your prescriptions.
Sildenafil is normally taken upon the need, 0.5 to 1 hour before sexual intercourse (a 50 mg sildenafil pill). However, you can administer the drug even up to 4 hours before the intercourse (in this case a 100 mg sildenafil tablet would be better). It shouldn't be taken more than one time a day.
Sildenafil can assist you to attain an erection during sexual stimulation. You won't get an erection by merely taking a 50 mg sildenafil pill. Thus, follow the instructions of your doctor.
During the coitus, if you feel nauseous or dizziness, numbness, pain, or tingling in the chest, neck, arms, or jaw, you should stop and contact your doctor immediately. You might be having a severe sildenafil side effect. The medicine should be stored at room temperature, far from heat and moisture.
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